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Salmon DNAFacial
The Salmon DNA Facial is an advanced regenerative skin treatment that uses PDRN — Polydeoxyribonucleotide — a highly purified compound extracted from salmon sperm (milt) cells. Despite the unusual source, PDRN shares approximately 97% genetic similarity with human DNA, making it exceptionally biocompatible and well-tolerated by the body with minimal risk of allergic reaction.
First approved by the Italian Medicines Agency in 1994 for wound healing, PDRN has been used clinically for over 30 years. It gained massive popularity in South Korea under the brand name Rejuran Healer and is now considered one of the gold standards of non-surgical skin rejuvenation in Asia, Europe, and increasingly worldwide. Unlike fillers that add volume or chemical peels that remove surface layers, PDRN works by communicating directly with your skin cells — triggering them to repair damaged tissue, produce collagen, and restore skin from within.
How It Works
A2A Receptor Activation
PDRN binds to adenosine A2A receptors, immediately suppressing pro-inflammatory cytokines and calming skin stress.
Nucleotide Salvage Pathway
DNA fragments are broken down into nucleotides that fibroblasts use as direct building blocks to accelerate collagen & elastin synthesis.
VEGF Upregulation
Boosts Vascular Endothelial Growth Factor — stimulating new blood vessel formation, improving nutrient delivery and circulation.
Fibroblast Proliferation
Significantly increases fibroblast activity — the cells responsible for producing collagen, elastin, and hyaluronic acid within the dermis.
SIRT1 Longevity Gene
2025 PLOS One study shows PDRN prevents SIRT1 longevity gene degradation from UV damage, actively reversing photo-ageing markers.
Deep Skin Hydration
Acts as a moisture magnet, drawing water into the dermis while stimulating natural hyaluronic acid production for long-term plumpness.
Step-by-step Procedure
In-depth consultation & skin mapping
Your dermatologist assesses your skin concerns, medical history, and treatment goals. Skin health, tone, existing conditions, and areas requiring targeted repair are carefully documented to build a personalised treatment plan.
Topical numbing cream
Topical numbing cream A 4–7% lidocaine numbing cream is applied under occlusion for 20–30 minutes. Most patients describe the subsequent injections as nothing more than light pressure — the numbing ensures a comfortable, near-painless experience.
Deep cleansing & sterilisation
The face is thoroughly cleansed and sterilised using chlorhexidine or 70% alcohol to ensure a completely sterile treatment surface before the PDRN is applied.
Treatment grid marking
The specialist marks precise treatment grids across the face to ensure even, consistent coverage and optimal distribution of the PDRN solution across all target zones.
PDRN delivery (injection / microneedling)
Hyaluronic acid, antioxidants (Vitamins A, C, E), and targeted peptides are simultaneously infused deep into the freshly cleansed skin via the vortex mechanism — providing intense hydration, free-radical protection, and nourishment at a cellular level.
Soothing mask & calming serum
A cooling, anti-inflammatory mask is applied post-treatment to reduce any immediate redness and settle skin inflammation. A calming serum with centella asiatica or similar is then applied.
SPF & aftercare briefing
Broad-spectrum SPF 30+ sunscreen is applied. Your specialist provides detailed personalised aftercare instructions to protect your skin and maximise the treatment's regenerative effect.
Key Benefits
Collagen & elastin revival
Clinical studies confirm PDRN boosts collagen production by 25–35%, directly improving skin firmness, resilience, and elasticity.
"Glass skin" radiance
Deeply repairs and hydrates the skin to deliver the coveted Korean "glass skin" — translucent, dewy, flawlessly smooth and luminous.
Deep cellular hydration
Stimulates natural hyaluronic acid production within the dermis, providing lasting plumpness and moisture from within — not just on the surface.
Fine lines & wrinkles
Reorganises and rebuilds collagen fibre networks, softening fine lines and reducing the depth of wrinkles progressively with each session.
Anti-inflammatory action
A2A receptor activation immediately calms chronic skin inflammation — ideal for rosacea-prone, sensitive, or post-procedure skin.
Acne scar repair
Accelerates tissue regeneration by up to 50%, visibly reducing the appearance of acne scars, enlarged pores, and uneven skin texture.
Fades pigmentation
Regulates melanin activity and promotes cell renewal to gradually fade post-inflammatory hyperpigmentation, dark spots, and sun damage.
Under-eye rejuvenation
Ideal for delicate periorbital areas — reduces crepiness, dark circles, and fine lines around the eyes with precise, targeted delivery.
Barrier & skin quality
Thickens both the epidermis and dermis layers over time, making skin more resilient to environmental stressors, UV, and pollution damage.